期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 47, 页码 16737-16740出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja103050x
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资金
- NSFC of China [20702040, 20832003, 20972118, 20972119]
A striking breakthrough to the frame of traditional cross-couplings/C-H functionalizations using an organocatalyst remains unprecedented. We uncovered a conceptually different approach toward the biaryl syntheses by using DMEDA as the catalyst to promote the direct C-H arylation of unactivated benzene in the presence of potassium tert-butoxide. The arylation of unactivated benzene with aryl iodides, or aryl bromides and even chlorides under the assistance of an iodo-group, could simply take place at 80 degrees C. The new methodology presumably involves an aryl radical anion as an intermediate. This finding offers an option toward establishing a new horizon for direct C-H/cross-coupling reactions.
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