期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 2, 页码 436-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja909105s
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The enantioselective conjugate addition of alkynyl nucleophiles has been a long-standing challenge in synthetic chemistry. This paper describes a highly practical asymmetric conjugate alkynylation of Meldrum's acid-derived acceptors using cinchonidine (<$100/kg) as the chiral mediator. The process provides practical access to chiral beta-alkynyl acids. Noteworthy attributes of the method are its broad scope, high functional-group compatibility, and ease of scalability.
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