期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 24, 页码 8376-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja902972w
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资金
- University of Pittsburgh
- American Chemical Society Petroleum Research Fund [PRF 47601-G10]
A porous anionic metal-organic framework, bio-MOF-1, constructed using adenine as a biomolecular building block is described. The porosity of this material is evaluated, its stability in biological buffers is studied, and its potential as a material for controlled drug release is investigated. Specifically, procainamide HCl is loaded into the pores of bio-MOF-1 using a simple cation exchange process. Exogenous cations from biological buffers are shown to affect the release of the adsorbed drug molecules.
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