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Corey-Chaykovsky Epoxidation of Twisted Amides: Synthesis and Reactivity of Bridged Spiro-epoxyamines

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 37, 页码 13246-13247

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AMER CHEMICAL SOC
DOI: 10.1021/ja906471q

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  1. National Institute of General Medical Sciences [GM-49093]

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The first example of a Corey-Chaykovsky epoxidation employing amides as substrates is described. Medium-bridged twisted amides serve as precursors to a family of isolable aminoepoxides. The reactivity of bridged spiro-epoxyamines is also investigated.

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