期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 46, 页码 16614-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja9061085
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资金
- Korea government (MEST) [2009-0079739]
- Korea Health 21 RD Project [A062254]
- Korea Health Promotion Institute [A062254] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2009-0079739] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The cyclodextrin covered porous silica nanoparticles (Si-MPs) exhibited enzyme responsive characteristics. The cyclodextrin gatekeepers on the surface of Si-MPs can be hydrolyzed by a-amylase to release guest molecules from the porous reservoir. The ester linkage in the stalk part of the cyclodextrin gatekeeper can also be cleaved by lipase to release guests from the channel. Our approach would provide a unique methodology for controlled delivery systems.
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