期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 5, 页码 1766-1774出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja807323a
关键词
-
资金
- Majesty's Government of Brunei Darussalam
- Universiti Brunei Darussalam
- EPSRC
- GlaxoSmithKline
- EPSRC [EP/F015690/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F015690/1] Funding Source: researchfish
The alkylation of amines by alcohols has been achieved using 0.5 mol % [Ru(p-cymene)Cl-2](2) with the bidentate phosphines dppf or DPEphos as the catalyst. Primary amines have been converted into secondary amines, and secondary amines into tertiary amines, including the syntheses of Piribedil, Tripelennamine, and Chlorpheniramine. N-Heterocyclization reactions of primary amines are reported, as well as alkylation reactions of primary sulfonamides. Secondary alcohols require more forcing conditions than primary alcohols but are still effective alkylating agents in the presence of this catalyst.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据