Versatile Pd(OTf)2.2H2O-Catalyzed ortho-Fluorination Using NMP as a Promoter

Pd(OTf)(2)center dot 2H(2)O-catalyzed ortho-fluorination of triflamide-protected benzylamines is reported. The use of N-fluoro-2,4,6-trimethylpyridinium triflate as the F+ source and NMP as a promoter is crucial for this reaction. The conversion of triflamide into a wide range of synthetically useful functional groups makes this fluorination protocol broadly applicable in medicinal chemistry and synthesis.