期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 25, 页码 8734-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja902410w
关键词
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资金
- Major Basic Research Development Program [2006CB806106]
- National Natural Science Foundation of China [20532050, 20672130, 20821002]
- Chinese Academy of Sciences, Shanghai Committee of Science and Technology
- Croucher Foundation of Hong Kong
A highly diastereo- and enantioselective cyclopropanation reaction was realized in the reaction of acyclic amides with monosubstituted allyl carbonates via Pd-catalysis using a ferrocene ligand with H as a substituent on an oxazoline ring, providing cyclopropane products having three chiral centers in yields of 67-83%, the dr ratio being 4-23:1, and ee being 83-97%. The presence of LiCl is important for the gain of high diastereo- and enantioselectivities of the reaction.
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