期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 6, 页码 2116-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja808862w
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资金
- Boehringer Ingelheim (Canada) Ltd
- NSERC (CRD)
- NSERC
- Swiss National Science Foundation
- Alfred P. Sloan Research Fellow
Selective alpha-C-H activation results in the synthesis of the first bridging metallaaziridine complex for the catalytic alpha-alkylation of primary amines. Reaction development led to the preparation of new Zr 2-pyridonate complexes for this useful transformation. No nitrogen protecting groups are required for this reaction, which is capable of assembling quaternary chiral centers a to nitrogen. Preliminary mechanistic investigations suggest bridging metallaaziridine species are the catalytically active intermediates for this alpha-functionalization reaction, while monomeric imido complexes furnish azepane hydroamination products.
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