4.8 Article

Detecting Vascular Biosignatures with a Colloidal, Radio-Opaque Polymeric Nanoparticle

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 42, 页码 15522-15527

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AMER CHEMICAL SOC
DOI: 10.1021/ja906797z

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  1. AHA [0835426N]
  2. NIH [NS059302, CAI 19342, HL073646]

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A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range.

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