期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 12, 页码 4216-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja900790v
关键词
-
资金
- NIH/NCI [1R21-CA12859]
- NATIONAL CANCER INSTITUTE [R21CA128529] Funding Source: NIH RePORTER
Dumbbeil-like Au-Fe3O4 nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The ptatin-Au-Fe3O4-Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC50) toward Sk-Br3 cells of 1.76 mu g of Pt/mL, which is lower than that needed for cisplatin (3.5 mu g/mL). The work demonstrates that the dumbbell-like Au-Fe3O4 NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据