期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 15, 页码 5372-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja9001162
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资金
- NSF [CHE-0555425]
- NIH [GM-080422]
- NCBC [2008-IDG-1010]
- Johnson&Johnson
Reaction of 1-methyl-imidazolidin-2-one (1) with 1-octene (10 equiv) catalyzed by a 1:1 mixture of (2b)AuCl [2b = 2-di-tert-butylphosphino-1,1'-binaphthyl] and AgSbF6 in dioxane at 100 degrees C for 24 h led to isolation of 1-methyl-3-(octan-2-yl)imidazolidin-2-one in 96% yield as a single regioisomer. A range of unactivated 1-alkenes and ethylene underwent gold(I)-catalyzed intermolecular hydroamination at or below 100 degrees C in excellent yield with high regioselectivity. Reaction of 1-alkenes with substituted imidazolidin-2-ones catalyzed by chiral bis(gold) phosphine complexes led to enantioselective intermolecular hydroamination with up to 78% ee.
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