期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 21, 页码 7212-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja901528b
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- NUS
- [R-143-000-337-112]
- [R-143-000-376-112]
We report that chiral bicyclic guanidine 1 is found to catalyze the isomerization of alkynes to chiral allenes with high enantioselectivities. This Bronsted base catalyzed 1,3-proton shift reaction, an efficient and atom economical reaction, proceeds through deprotonation and protonation sequences. The axial chirality of the allenes is efficiently transferred to functionalized butenolides and cycloaddition products. We also successfully demonstrate the stereospecific synthesis of butenolide through allenoate cyclization with a catalytic cationic Au(I) complex.
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