期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 34, 页码 12109-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja906115a
关键词
-
资金
- National Institutes of Health [GM-29028]
The final synthetic challenges associated with (+)-sorangicin A have been overcome, thus leading to the first total synthesis of this complex macrolide antibiotic. Highlights of the highly convergent synthesis include two Julia-Kocienski olefinations to unite three advanced fragments with high E-stereoselectivity. Critical to the final-stage success was the use of a carefully defined Stille coupling and a Mukaiyama macrolactonization as well as Lewis and protic acid-promoted deprotections carefully designed to suppress E/Z isomerization and/or destruction of the delicate (Z,Z,E)-trienoate linkage.
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