4.8 Article

Rewritable Glycochips

期刊

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 22, 页码 7755-7761

出版社

AMER CHEMICAL SOC
DOI: 10.1021/ja901294r

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资金

  1. BBSRC [BB/E004350/1] Funding Source: UKRI
  2. EPSRC [EP/G026688/1, EP/E000614/1] Funding Source: UKRI
  3. Biotechnology and Biological Sciences Research Council [EGA17763, BB/E004350/1] Funding Source: Medline
  4. Biotechnology and Biological Sciences Research Council [BB/C510824/1, BB/E004350/1, EGA17763] Funding Source: researchfish
  5. Engineering and Physical Sciences Research Council [EP/D023335/1, GR/T26542/01, EP/E000614/1, EP/G026688/1, EP/D023343/1] Funding Source: researchfish

向作者/读者索取更多资源

We describe microarraying of carbohydrates for protein screening using either disulfide bridge or Schiff base imine immobilization chemistries on plasmachemical deposited functional nanolayers. The commonly observed issue of nonspecific background binding of proteins is overcome by spotting carbohydrates through a protein-resistant overlayer yielding spatially localized interaction with a reactive functional underlayer.

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