期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 37, 页码 13399-13409出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja904007p
关键词
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资金
- BBSRC
- Cancer Research UK
- Human Frontier Long-term Fellowship [LT0798/2005]
- National Science Council of the Republic of China, Taiwan [NSC97-2917-1-564-102]
- European Union [R113-026145]
Guanine-rich DNA sequences with the ability to form quadruplex structures are enriched in the promoter regions of protein-coding genes, particularly those of proto-oncogenes. G-quadruplexes are structurally polymorphic and their folding topologies can depend on the sample conditions. We report here on a structural study using solution state NMR spectroscopy of a second G-quadruplex-forming motif (c-kit2) that has been recently identified in the promoter region of the c-kit oncogene. In the presence of potassium ions, c-kit2 exists as an ensemble of structures that share the same parallel-stranded propeller-type conformations. Subtle differences in structural dynamics have been identified using hydrogen-deuterium exchange experiments by NMR spectroscopy, suggesting the coexistence of at least two structurally similar but dynamically distinct substates, which undergo slow interconversion on the NMR timescale.
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