期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 14, 页码 5034-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja9001579
关键词
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资金
- NIH [GM17880-38]
Cytochrome c oxidase (CcO) catalyzes the four-electron reduction of oxygen to water, the one-electron reductant Cytochrome c (Cytc) being the source of electrons. Recently we reported a functional model of CcO that electrochemically catalyzes the four-electron reduction of O-2 to H2O (Collman et al. Science 2007, 315, 1565). The current paper shows that the same functional CcO model catalyzes the four-electron reduction of O-2 using the actual biological reductant Cytc in a homogeneous sotution. Both single and steady-state turnover kinetics studies indicate that O-2 binding is rate-determining and that O-O bond cleavage and electron transfer from reduced Cytc to the oxidized model complex are relatively fast.
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