期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 34, 页码 12088-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja900228j
关键词
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资金
- National Institutes of Health [GM076251]
In this Communication, we show that peptide nucleic acids (PNAs) with lengths of 15-20 nucleotides, when preorganized into a right-handed helix, can invade mixed-sequence double-helical B-form DNA (B-DNA). Strand invasion occurs in a highly sequence-specific manner through direct Watson-Crick base pairing. Unlike the previously developed double-duplex invasion strategy, which requires simultaneous binding of two strands of pseudocomplementary PNAs to DNA, only a single strand of gamma PNA is required for invasion in this case, and no nucleobase substitution is needed.
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