期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 42, 页码 15118-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja907268g
关键词
-
资金
- National Science Foundation [CHE-0717618]
An aluminum complex was found to be high yielding and enantioselective for the addition of cyanide to aldimines and ketimines. Although catalytic asymmetric addition of cyanide to imines to generate a-amino-protected nitrites (the Strecker reaction) has been extensively studied in the past, alternative, easier-to-handle reagents for this process are required for modern organic synthesis. To date, there are a limited number of reports utilizing alternative sources of cyanide other than KCN/HCN or TMSCN for this important reaction. The present catalyst provides uniformly high enantioselectivity for aromatic, heteroaromatic, and aliphatic aldimines and ketimines using ethyl cyanoformate as the cyanide source.
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