期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 23, 页码 8102-8107出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja900225w
关键词
-
资金
- Max Planck Society
- ANPCyT
- CONICET
- UBACyT
- DFG Center for Molecular Physiology of the Brain (DFG CMPB)
- Cluster of Excellence 171 of the CMPB
- UBA
Quantum dots multifunctionalized with the amyloid protein (x-synuclein act at nanomolar concentrations as very potent inducers of the aggregation of micromolar-millimolar bulk concentrations of the protein in vitro and in cells. Fibrillation in live cells, a process diagnostic of Parkinson's disease, is accelerated up to 15-fold with only similar to 100 nanoparticles. The combination with a tetracysteine-tagged form of alpha-synuclein specific for fluorogenic biarsenicals constitutes a very sensitive system for studying pathological amyloid formation in cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据