期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 37, 页码 13232-13233出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja905125b
关键词
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资金
- NIDCR NIH HHS [U01 DE017788, U01 DE017788-04] Funding Source: Medline
In this communication, we describe the integration of microarray sensor technology with logic capability for screening combinations of proteins and DNA in a biological sample. In this system, we have demonstrated the use of a single platform amenable to both protein detection and protein-DNA detection using molecular logic gates. The pattern of protein and DNA inputs results in fluorescence outputs according to a truth table for AND and INHIBIT gates, thereby demonstrating the feasibility of performing medical diagnostics using a logic gate design. One possible application of this technique would be direct screening of various medical conditions that are dependent on combinations of diagnostic markers.
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