期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 18, 页码 6492-6497出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja809656k
关键词
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资金
- European Research Council [201749]
- Human Frontier Science Program [80/2003]
- French Ministry of Research and Education
- Boehringer Ingelheim Fonds
- Fonds der Chemischen Industfie (FCI)
- Bundesministerium fur Bildung und Forschung (BMBF)
- European Research Council (ERC) [201749] Funding Source: European Research Council (ERC)
Nucleic acid-templated reactions leading to a fluorescent product represent an attractive strategy for the detection and imaging of cellular nucleic acids. Herein we report the use of a Staudinger reaction to promote the reduction of profluorescent azidorhodamine. The use of two cell-permeable GPNA probes, one labeled with the profluorescent azidorhodamine and the other with trialkylphosphine, enabled the detection of the mRNA encoding O-6-methylguanine-DNA methyltransferase in intact cells.
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