期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 22, 页码 7518-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja9011386
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We describe a new method to immobilize a given number of oligonucleotides (ODNs) on gold nanoparticles (AuNPs) in a specific arrangement directed by a geometrical template made of DNA. The basic strategy is as follows. First, a set of thiolated ODNs for immobilization and a nonthiolated template are hybridized to make a DNA nanostructure. Next, the DNA nanostructure is reacted with AuNPs via the thiol groups to form a complex of the AuNP and the DNA nanostructure. Finally, the intended AuNP/ODN conjugate is obtained by removing the template from the complex. The above strategy enables us to make various formats of AuNP/ODN conjugates simply by changing the design of the DNA nanostructure. We demonstrate proof-of-concept experiments using a linear design of the DNA nanostructure.
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