期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 37, 页码 13210-13211出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja9047762
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资金
- NIGMS NIH HHS [R01 GM059417, R01 GM059417-10, GM-59417] Funding Source: Medline
The Pt-catalyzed enantioselective addition of bis(pinacolato)diboron to simple monosubstituted alkenes is described. This reaction occurs in the presence of a readily available chiral phosphonite ligand and is effective with a variety of terminal alkene substrates. importantly, the reaction can operate with catalyst loadings of only 1 mol % Pt. White oxidation of the intermediate 1,2-bis(boronate) ester provides the chiral 1,2-diol as the reaction product, the intermediate may also be subjected to homologation/oxidation to furnish a chiral 1,4-diol as the reaction product.
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