期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 1, 页码 66-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja804947u
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资金
- National Science Council of Republic of China
The Fe3O4 nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.
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