期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 10, 页码 3464-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja900155x
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资金
- NIGMS NIH HHS [R01 GM073932-04, R01 GM073932, R01 GM074774] Funding Source: Medline
The first transition metal catalyzed asymmetric carboalkoxylation reaction of propargyl esters is described. The (R)-MeO-DTBM-BIPHEP(AuCl)(2)-catalyzed reactions allow for the construction of benzopyrans containing quaternary stereocenters with excellent enantioselectivity. Experimental evidence supports a mechanism proceeding via the generation of a stabilized carbocation from an allylic oxonium intermediate and subsequent trapping by a chiral allylgold(I) spieces.
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