4.8 Article

Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry

期刊

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 43, 页码 14139-14143

出版社

AMER CHEMICAL SOC
DOI: 10.1021/ja805392f

关键词

-

资金

  1. Office of Naval Research [N000140510501]
  2. NIH [GM077173]
  3. NSF Center for Hierarchical Manufacturing [DM1-0531171]

向作者/读者索取更多资源

Gold nanoparticles (AuNPs) are highly promising candidates as drug delivery agents into cells of interest. We describe for the first time the multiplexed analysis of nanoparticle uptake by cells using mass spectrometry. We demonstrate that the cellular uptake of functionalized gold nanoparticles with cationic or neutral surface ligands can be readily determined using laser desorption/ionization mass spectrometry of cell lysates. The surface ligands have mass barcodes that allow different nanciparticles to be simultaneously identified and quantified at levels as low as 30 pmol. Using this method, we find that subtle changes to AuNP surface functionalities can lead to measurable changes in cellular uptake propensities.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据