期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 47, 页码 15784-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja807078y
关键词
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资金
- National Science Foundation [CHE-0701540]
- National Institutes of Health [GM68729]
- National 973 Project of China [2007CB936003]
Oligoamide macrocycles 1d and 1e, which carry membrane-compatible side chains and contain a hydrophilic, noncollapsible cavity, were found to mediate high ion flux across a lipid bilayer, as demonstrated by results from Na-23 NMR and planar bilayer conductance measurements. The measured transmembrane single channel currents are very high, rivaling those typically associated with pore-forming protein toxins. The obtained results have demonstrated the promise of developing large, highly conducting channels based on nanopores formed by oligoamide macrocycles.
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