期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 14, 页码 4598-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja8001293
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资金
- Engineering and Physical Sciences Research Council [GR/S23612/01] Funding Source: researchfish
Choline is a precursor of cellular phospholipid metabolism that provides Magnetic Resonance (MR) and Positron Emission Tomography (PET) biomarkers for cancer detection and response assessment. Employing Dynamic Nuclear Polarization we show that the MR signal of N-15 in choline can be enhanced by at least 4 orders of magnitude with a relaxation time of ca. 4 min, providing a method to observe the action of choline kinase, an important target for novel cancer therapeutics.
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