期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 15, 页码 5008-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja801436j
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资金
- NCI NIH HHS [U54-CA119343] Funding Source: Medline
A Trojan horse PRINT particle composition was developed that incorporates a reductively labile cross-linker to achieve activated release of doxorubicin in vitro. Particles of discrete size and shape (cube side.. length = 2 mu m) containing 30 wt % of a disulfide-based cross-linker and 2 wt % doxorubicin were synthesized. This PRINT composition was shown to release doxorubicin in response to a reducing environment as measured by flow cytometry and was found to be highly proficient at killing HeLa cells in vitro.
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