期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 37, 页码 12206-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja8020268
关键词
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资金
- Korea Science and Engineering Foundation (KOSEF)
- Ministry of Land, Transport, and Maritime Affairs (MLTM), Korea
- Ministry of Education, Science & Technology (MEST)
- Seoul Science Fellowship award
- BK21 fellowship awards
- Korea Institute of Marine Science & Technology Promotion (KIMST) [B10400207A290100900] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2006-02375, 2005-00001, 2006-04590, 과06A1501] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We developed a novel fluorescent core skeleton, 1,2-dihydropyrrolo[3,4-beta]indolizin-3-one, by complexity-generating one-pot reactions through 1,3-dipolar cyclization followed by oxidative aromatization. This fluorescent core skeleton can accommodate various wavelengths of emission maxima by changing the electronic properties of substituents, which was postulated by computational studies. The full-color-tunable emission maxima were achieved with a single core skeleton by changing the substituents using the combinatorial approach. These novel fluorophores have excellent photophysical and photochemical properties: moderate to excellent quantum yields, resistance to the photobleaching, pH-independent fluorescence, large Stokes shifts, druglike lipophilicity for membrane permeability, etc. Further, we successfully demonstrated the bioapplication of fluorophores B1 and B5 in the immunofluorescence for visualizing cellular compartments of HeLa cells.
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