Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier

One-pot approach to couple the crystallization of CaCO3 nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.