Detection of Breast Cancer Microcalcifications Using a Dual-modality SPECT/NIR Fluorescent Probe

Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the gold standard by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.