期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 47, 页码 15788-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja807156b
关键词
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资金
- National Institute of General Medical Sciences [GM65519]
- Swiss National Science Foundation
- Roche Research Foundation
- Novartis DROP fellowship
Substitution of one pyridine by pyrazine in each DPA appendage of ZP1 leads to a new zinc sensor, ZPP1, with a modified background fluorescence and zinc affinity. ZPP1 exhibits a two-step zinc response during fluorescence titrations, which leads to a new method for zinc quantification. The ability of ZPP1 to image and quantify zinc was demonstrated in pancreatic Min6 cells.
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