Oxidation State-Specific Fluorescent Method for Palladium(II) and Platinum(IV) Based on the Catalyzed Aromatic Claisen Rearrangement

Contamination of active pharmaceutical ingredients and healthcare products with oxidized forms of palladium and platinum are important problems. We report a convenient fluorogenic probe based on the catalyzed aromatic Claisen rearrangement capable of detecting Pd-II and Pt-IV. Using this probe, we can fluorescentty detect Pd-III in functionalized organic compounds and Pt-IV in Pt-0-water without sample pretreatment. This method may find broad applications in the pharmaceutical industry, the environment, and Pd/Pt quality control.