期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 49, 页码 16786-16790出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja805936v
关键词
-
资金
- National Institutes of Health [HL25848]
- NSF predoctoral fellowship
- Eli Lilly Co.
The aglycone of pluraflavin A (2) has been synthesized. The key features of this synthesis include a 1,3-dipolar cycloaddition between a nitrile oxide (cf. 14) and an olefin (22) to yield an isoxazoline followed by subsequent conversion into the gamma-pyrone of pluraflavin A. The epoxide moiety linked to the pyrone is installed prior to Diels-Alder installation of the D ring, which allows access to a number of potentially active cytotoxic intermediates en route to the final compound. The preliminary in vitro results of two such compounds are also included with the racemic title compound exhibiting cytotoxicity in the nanomolar range.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据