期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 47, 页码 15770-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja808023y
关键词
-
资金
- National Natural Science Foundation of China [20732003]
- Ministry of Education [20070610019]
Highly enantioselective carbonyl-ene reaction of glyoxal derivatives and glyoxylate with various alkenes was accomplished using a novel nickel (II)-N,N'-dioxide complex under mild conditions, which facilitated the asymmetric synthesis of biologically interesting a-hydroxy carbonyl compounds. Various aromatic, aliphatic, and heteroaromatic glyoxal derivatives, as well as glyoxylate, could be tolerated in this system and afforded the corresponding adducts in excellent enantioselectivities (97->99% ee) with high yields. Moreover, the catalyst loading could even be decreased to 1 mol%, while the enantioselectivity was basically maintained.
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