期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 27, 页码 8741-8747出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja800793t
关键词
-
The mechanism of the Hantzsch ester hydrogenation of imines catalyzed by chiral BINOL-phosphoric acid has been investigated using DFT methods. Despite the importance of this reaction, there are a number of possible detailed mechanisms, and the preferred pathway has not been firmly established. Our calculations show that the catalyst not only activates the imine group for the reaction by acting as a Bronsted acid but also establishes an interaction with the Hantzsch ester that can lead to an explanation for the enantioselectivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据