期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 2, 页码 410-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja0775467
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资金
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [840684] Funding Source: National Science Foundation
- NIBIB NIH HHS [R01 EB002189-07, R01 EB002189] Funding Source: Medline
- PHS HHS [R01 1056047] Funding Source: Medline
The use of potentiometric microsensors is demonstrated here for the first time to detect DNA hybridization. Cadmium sulfide nanocrystal labels bound on a secondary oligonucleolide are dissolved and detected with cadmium-selective microelectrodes exhibiting DNA detection limits of ca. 2 fmol in a 200 mu sample.
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