期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 40, 页码 13190-13191出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja804607v
关键词
-
资金
- NSF [MCB 0451448]
A new type of double-stranded DNA targeting format by formation of a Janus-Wedge (J-W) triple helix is described. The wedge residue W-1 is used for A-T and T-A base pairs while W-2 is used for G-C and C-G base pairs. Both wedge residues are attached to a PNA backbone that is designed to insert the probe strand into double-stranded DNA and base pair with bothe Watson-Crick faces. To study the stability of such an assembly, we have examined the formation of the J-W triplex with various sequences.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据