期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 44, 页码 14436-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja806519m
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资金
- NCI NIH HHS [1R21CA1285-1, R21 CA128529-02, R21 CA128529-01] Funding Source: Medline
We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 mu g/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications.
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