Highly anti-selective asymmetric nitro-Mannich reactions catalyzed by bifunctional amine-thiourea-bearing multiple hydrogen-bonding donors

Highly anti-selective and enantioselective nitro-Mannich reactions have been achieved for a broad spectrum of substrates catalyzed by chiral bifunctional multiple hydrogen-bonding-donor amine-thioureas. Multiple hydrogen-bonding donors play a significant role in accelerating reactions and improving yields, diastereoselectivities, and enantioselectivities.