期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 33, 页码 10836-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja8040477
关键词
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资金
- National Institutes of Health [P20 GM072069, R01 CA108468, U01HL080711, U54CA119338]
- NIH biotechnology training [T32 GM08433]
- NSF-IGERT program
- Whitaker Foundation
We report quenching and chemical degradation of polymer-coated quantum dots by reactive oxygen species (ROS), a group of oxygen-containing molecules that are produced by cellular metabolism and are involved in both normal physiological and disease processes such as oxidative signaling, cancer, and atherosclerosis. A major new finding is that hypochlorous acid (HOCl) in its neutral form is especially potent in degrading encapsulated QDs, due to its small size, neutral charge, long half-life, and fast reaction kinetics under physiologic conditions. Thus, small and neutral molecules such as HOCl and hydrogen peroxide (H2O2) are believed to diffuse across the polymer coating layer, leading to chemical oxidation of sulfur or selenium atoms on the OD surface. This etching process first generates lattice structural defects (which cause fluorescence quenching) and then produces soluble metal
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