期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 24, 页码 7568-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja803158y
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资金
- NINDS NIH HHS [R01 NS012389, NS-12389] Funding Source: Medline
The first total synthesis of (+/-)-actinophyllic acid (1) is reported. Key steps of this synthesis include an intramolecular oxidative coupling of ketone and malonic ester enolates and an aza-Cope-Mannich rearrangement that assembled the core structure of the natural product's unique ring system. The synthesis was accomplished from di-tert-butyl malonate in 8% overall yield by a concise sequence that proceeds by way of only seven isolated intermediates.
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