期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 130, 期 48, 页码 16130-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja805558k
关键词
-
资金
- Franco-Algerian Intergouvernemental Program
- EU
An approach for the synthesis of carbonic anhydrase (CA, EC 4.2.1.1) inhibitor coated gold nanoparticles is reported. This nanomaterial selectively inhibited the tumor-associated isoform CA IX overexpressed in hypoxic cancers over the ubiquitous, cytosolic housekeeping isozymes CA I and II and was membrane impermeant. As CA IX has an extracellular active site, the new nanomaterial which is confined to the extracellular space may be useful for imaging and treatment of hypoxic tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据