期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 70, 期 6, 页码 -出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2013.12.037
关键词
actinic keratosis; basal cell carcinoma; Bowen disease; erythroplasia of Queyrat; lentigo maligna; melanoma; Paget disease; skin cancer; squamous cell carcinoma; topical treatment.
类别
The purpose of the paper is to provide an in-depth, evidence-based analysis of the clinical use of topical treatments for skin cancer. A comprehensive review of topical drugs has been performed, including 5-fluorouracil, imiquimod, diclofenac, ingenol mebutate, retinoids, resiquimod, piroxicam, dobesilate, and betulinic acid. The evaluated studies were rated according to their level of evidence level (I-V), as indicated by recent guidelines for evidence-based medicine, The Oxford 2011 Levels of Evidence. Therapeutic response is generally related to tumor type, extent, and localization, and also to patient compliance. Careful patient selection is required in order to achieve the desired goal of complete tumor clearance.
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