期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 66, 期 3, 页码 E109-E121出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2011.05.017
关键词
diagnosis; Duke criteria; dysplastic nevus; histopathology; in vivo confocal microscopy; melanoma
类别
资金
- Istituto Superiore di Sanita-Italy [527/B/3A/4]
Background: Dysplastic nevi are thought to be precursors of melanoma during a stepwise process. However, this concept is still controversial and precise correlation between clinical and histopathologic features is lacking. In vivo confocal microscopy represents a noninvasive imaging technique producing horizontal sections at nearly histopathologic resolution. Objective: We sought to determine whether specific histologic features in dysplastic nevi have reliable correlates on confocal microscopy and to develop an in vivo microscopic grading system. Methods: Sixty melanocytic lesions with equivocal dermatoscopic aspects, corresponding to 19 nondys-plastic nevi, 27 dysplastic nevi, and 14 melanomas, were analyzed by confocal microscopy and histopathology, using the Duke grading criteria. Results: All architectural and cytologic features of the Duke grading score had significant reflectance confocal microscopy correlates. Confocally, dysplastic nevi were characterized by a ringed pattern, in association with a meshwork pattern in a large proportion of cases, along with atypical junctional cells in the center of the lesion, and irregular junctional nests with short interconnections. A simplified algorithm was developed to distinguish dysplastic nevi from melanoma and nondysplastic nevi. The contemporary presence of cytologic atypia and of atypical junctional nests (irregular, with short interconnections, and/or with nonhomogeneous cellularity) was suggestive of histologic dysplasia, whereas a widespread pagetoid infiltration, widespread cytologic atypia at the junction, and nonedged papillae suggested melanomadiagnosis. Limitations: A small number of cases were evaluated because of the necessity to analyze numerous histopathologic and confocal features. Conclusion: The possibility to detect dysplastic nevi in vivo may lead to an appropriate management decision. (J Am Acad Dermatol 2012;66:e109-21.)
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