期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 64, 期 2, 页码 352-404出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2010.08.037
关键词
Sezary syndrome
类别
资金
- Merck
Sezary syndrome (SS) has a poor prognosis and few guidelines for optimizing therapy. The US Cutaneous Lymphoma Consortium, to improve clinical care of patients with SS and encourage controlled clinical trials of promising treatments, undertook a review of the published literature on therapeutic options for SS. An overview of the immunopathogenesis and standardized review of potential current treatment options for SS including metabolism, mechanism of action, overall efficacy in mycosis fungoides and SS, and common or concerning adverse effects is first discussed. The specific efficacy of each treatment for SS, both as monotherapy and combination therapy, is then reported using standardized criteria for both SS and response to therapy with the type of study defined by a modification of the US Preventive Services guidelines for evidence-based medicine. Finally, guidelines for the treatment of SS and suggestions for adjuvant treatment are noted. (J Am Acad Dermatol 2011;64:352-404.)
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