期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 64, 期 2, 页码 423-431出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2009.11.692
关键词
cutaneous T-cell lymphoma; Epstein-Barr virus; herpesvirus; human T-lymphotrophic virus; infection; Merkel cell polyomavirus; retrovirus
类别
资金
- NCI NIH HHS [P50 CA121973] Funding Source: Medline
Infectious agents have long been suspected as potential causative agents in cutaneous T-cell lymphoma (CTCL). Tissues of patients with CTCL have been evaluated for evidence of infection with a number of agents, including Staphylococcus aureus, retroviruses, and herpesviruses. These studies have failed to reveal a consistent association of CTCL with investigated agents. However, there is substantial evidence suggesting a potential role of a yet unidentified virus in CTCL. This article will review the findings of studies exploring potential roles of infectious agents in CTCL. In addition, we investigated CTCL tissues for evidence of infection with Merkel cell polyomavirus, a novel polyomavirus that was recently discovered as a probable carcinogenic agent in Merkel cell carcinoma. Cutaneous lesions demonstrating mycosis fungoides were stained with a monoclonal antibody against the Merkel cell polyomavirus T antigen, along with appropriate positive and negative controls. Immunohistochemical stains produced negative results in all examined mycosis fungoides specimens. These findings, which suggest a lack of association of CTCL with Merkel cell polyomavirus, add to the current body of knowledge regarding infectious agents and CTCL. (J Am Acad Dermatol 2011;64:423-31.)
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