期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 65, 期 6, 页码 1145-1151出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2010.09.009
关键词
antioxidant; epidemiology; skin cancer; squamous cell carcinoma; supplement; vitamin
类别
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [K23 AR 051037, K24 AR 052667]
- National Cancer Institute [R01 CA 098838, K05CA154337]
Background: Laboratory and epidemiologic studies suggest that certain dietary supplements may alter risk of cutaneous squamous cell carcinoma (SCC). Objective: We sought to examine the association between supplement use and SCC risk. Methods: Cases (n = 415) were defined as Kaiser Permanente Northern California members with a pathology-verified SCC in 2004 and control subjects (n = 415) were age-, sex-, and race-matched members with no history of skin cancer. Supplement use and SCC risk factors were ascertained by questionnaire. Associations of SCC with use of multivitamins; vitamins A, C, D, and E; and grape seed extract were estimated as odds ratios and 95% confidence intervals using conditional logistic regression. Models were adjusted for SCC risk factors and other supplement use. Results: Grape seed extract users had a significantly decreased risk of cutaneous SCC (adjusted odds ratio 0.26, confidence interval 0.08-0.89, P = .031). Multivitamin use was associated with a borderline significant reduction in SCC risk (adjusted odds ratio 0.71, confidence interval 0.51-1.00, P = .049). Use of vitamins A, C, 0, and E was not associated with SCC risk. Limitations: The data may be prone to recall and selection bias because of the case-control design. No information was obtained on dose or duration of supplement use. Conclusions: Use of grape seed extract may be associated with a decreased risk of cutaneous SCC. The other supplements included in our study did not reveal clear associations with SCC risk. (J Am Acad Dermatol 2011;65:1145-51.)
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